Phase-Appropriate Plasmid DNA with Industry-Leading Titer, High Quality & Fast Turn-Around Times

Rapid, high-quality plasmid DNA manufacturing backed by proprietary technologies for every stage of advanced therapy drug development.

High-quality plasmid DNA with titers up to 2.5 g/L and >95% supercoiled purity supports biotherapeutic production while optimizing cost per gram. Our tailored service levels—Pre-CMC, IND Pro™, and cGMP—align plasmid quality with each stage of development, ensuring regulatory compliance and accelerating time-to-market. For all of our services, our streamlined process enhances downstream efficiency and scalability.

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Plasmid CDMO solutions for every stage of development

Quality is cornerstone in your journey from discovery to commercialization. We understand that your requirements evolve throughout this critical path. We offer three tailored service levels - Pre-CMC, IND Pro™ and cGMP - for every stage of development. This tiered approach allows you to align plasmid quality with your project phase and regulatory requirements, optimizing both cost and development speed.

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Your Plasmid DNA Options for Every Stage of Advanced Therapy Development

ProBio has successfully produced plasmid DNA for more than 300 clinical trial batches for the past 6 years, using proprietary platform technology to manufacturing DNA for cell therapy, gene therapy, DNA/mRNA vaccine, or RNA template guide for non-viral application.

Whether you require 500 mg for a tox batch or 300 g for early phase trial, we provide the most affordable, high supercoiled plasmid DNA that meets you everywhere you are in your program journey. We understand that your requirements evolve throughout this critical path. We offer three tailored service levels - Pre-CMC, IND Pro™ and cGMP - for every stage of development. This tiered approach allows you to align plasmid quality with your project phase and regulatory requirements, optimizing both cost and development speed.

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Why choose ProBio for your plasmid manufacturing

ProBio combines global expertise with personalized attention to meet your plasmid manufacturing needs. From production to scalable facilities and rigorous quality control, our plasmid services deliver reliability and efficiency at every stage.

Phase-appropriate plasmid production

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Tailor plasmids to every stage of development—preclinical, clinical, and commercial. With GMP compliance and robust quality standards, we provide precise plasmid solutions for IND submissions, process validations, and regulatory filings.

Optimized manufacturing processes

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Increase recovery rates, reduce purification steps, and streamline plasmid production. ProPlus™ supports high- and low-copy plasmids while maintaining >95% supercoiled purity and <1 EU/mg endotoxin levels. Optimized at every step, it ensures consistent quality for small- and large-scale production.

Superior quality control standards

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Ensure >95% supercoiled plasmid purity, endotoxin levels below 1 EU/mg, and <1% host cell RNA. Our rigorous QC testing covers sterility, identity, and impurity removal, providing reliable plasmids essential for high-stakes applications like gene therapy and AAV manufacturing.

Scalable, flexible manufacturing

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Transition seamlessly between project scales with GMPro and GMP-grade facilities offering fermentation capacities of 10L to 30L. Our similar process parameters across scales ensure stability, reproducibility, and efficiency for both small and large production needs.

Global expertise with personalized attention

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Combine the resources and expertise of a global CDMO with the focused attention of a smaller partner. With more than 50 successful clinical-stage projects and 1 commercial-stage project success, we deliver tailored, localized solutions supported by FDA DMF-registered plasmids.

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Plasmid manufacturing service

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In Stock, Drug-Master File Ready Plasmids for Adeno-Associated Virus Production

ProBio offers plasmids for triple-transient transfection AAV manufacturing process with one GOI-containing transfer plasmid, the AAssistV™ pHelper plasmid, and the AAssistV™ pRC Rep/Cap plasmid—to ensure high-performance AAV production.

Our Solutions are Designed to Meet AAV Manufacturing Needs

  • High performance AAV vector production with robust titers up to 15 g/L
  • Reach the clinic quickly with ease using our Drug-Master File for IND submission
  • Scalable manufacturing processes to adapt to various demands for clinical and commercial production needs

Proven excellence in plasmid manufacturing

Our track record showcases unmatched quality, scalability, and regulatory success in plasmid CDMO services.

95%+ Supercoiled Purity

Reliable plasmids for critical therapies.

2.5 g/L Plasmid Titers

High-yield fermentation processes.

60+ IND and Clearances

Proven regulatory compliance expertise.

400+ Plasmid and Viral Vector Successful Batches Delivered

Supporting diverse therapy needs.

300+ Clinical Plasmid Successful Batches Delivered

Extensive clinical-stage expertise.

5-2000 L Flexible Capacity

Seamless scaling for all stages.

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In Stock, Drug-Master File Ready Plasmids for Lentiviral Vector Production

Our lentiviral vector (LVV) plasmid solutions provide high-quality, FDA-compliant vectors using a triple-helper system and LentiBone™ transfer backbone to ensure high titer production for your lentiviral vectors.

Comprehensive solutions for lentiviral vector production

  • Get consistent LVV vector yields with titers up to 1x10⁷ TU/mL
  • Accelerate approval readiness with FDA DMF-registered LentiHelper™
  • Scale manufacturing efficiently with flexible Lentibone™ transfer backbone